Centene Corporation is a large publicly traded company and a multi-line managed care enterprise that serves as a major intermediary for both government-sponsored and privately insured health care programs. It is a healthcare insurer that focuses on managed care for uninsured, underinsured, and low-income individuals. Centene is the second-largest publicly traded corporation based in the state of Missouri. It ranked No. 42 in the 2020 Fortune 500 list of the largest United States corporations by total revenue.